2023 Infectious Diseases Annual Research Symposium Featuring the Inaugural J. Russell Little, MD Lecture

Agenda

Jun 22, 2023
1:00 – 5:30 pm
ID Annual Symposium
Eric P. Newman Education Center, 320 S Euclid Ave, St. Louis, MO 63110

12:30 p.m.	In person attendee check-in
1:00 p.m.	EPNEC Seminar Room B Welcome and Introductory Remarks William G. Powderly, MD and Jennifer A. Philips, MD, PhD Co-Directors, Division of Infectious Diseases, Washington University School of Medicine in St. Louis
1:05 p.m.	*INAUGURAL J. RUSSELL LITTLE, MD LECTURE* Advances in Tuberculosis Prevention and Treatment: Many reasons to be hopeful Amita Gupta, MD, MHS, Chief, Division of Infectious Diseases, Johns Hopkins School of Medicine Professor of Medicine
Selected oral presentations Part 1 2:00 p.m. – 3:00 p.m.	2:00 p.m. Patrick Olson, MD PhD Abstract #30: Durable murine colonization with Staphylococcus aureus using a novel model of neonatal colonization 2:12 p.m. Armaghan-e-Rehman Mansoor, MD Abstract #4: Healthcare personnel at non-acute care facilities are at risk of COVID-19 infection from workplace and community exposures 2:24 p.m. Alaullah Sheikh, PhD Abstract #27: Enterotoxigenic E. coli toxins impair normal intestinal epithelial cell maturation 2:36 p.m. Valerie Yuenger, PharmD Abstract #31: Impact of the BioFire® FilmArray® Pneumonia Panel on Antibiotic Prescribing 2:48 p.m. Andrew Roth, MD Abstract #28: Disruption Of 3Î²-hydroxysteroid Dehydrogenase In Mycobacterium Tuberculosis Leads To Increased Virulence And Altered Inflammatory Response
3:00 p.m.	Break (refreshments)
Selected oral presentations Part 2 3:15 p.m. – 4:15 p.m.	3:15 p.m. Patrick Ching, MD Abstract #3: Epidemiology of Central Line-Associated Bloodstream Infections Present on Hospital Admission 3:27 p.m. Marilia Rita Pinzone, MD Abstract #24: CARD8 activation in myeloid cells as a driver of chronic inflammation in HIV infection 3:39 p.m. Kevin Montes, MD Safety of moxidectin combination therapy for individuals living in onchocerciasis and lymphatic filariasis endemic areas 3:51 p.m. Priyal Pal, MD, PhD Abstract #10: What determines HIV tropism in vivo? 4:03 p.m. Donald Hong, MD Title: : Improved PrEP delivery via telemedicine during the COVID-19 pandemic in a traditional sexual health clinic.
4:15 p.m.	Refreshments and Poster Session in EPNEC Great room B – Poster Presentations (until 5:30 p.m.)

POSTERS BY CATEGORY

Clinical

A clinical prediction model for mortality in patients with Candida bloodstream infection: Implications for clinical trial recruitment.
Kevin Montes, Adriana M. Rauseo, Julio C. Zuniga-Moya, Andrej Spec
Metabolomic identification of diagnostic biomarkers in post-mastectomy breast reconstruction fluid specimens.
John Wildenthal, Margie A Olsen, Hung D Tran, Jeffrey P Henderson
Epidemiology of Central Line-Associated Bloodstream Infections Present on Hospital Admission
Patrick Ching, Carlos Mejia-Chew, MD

Epidemiology & Prevention

4. Healthcare personnel at non-acute care facilities are at risk of COVID-19 infection from workplace and community exposures.
Armaghan-e-Rehman Mansoor, Caroline A. O’Neil, David McDonald, Victoria J. Fraser, Hilary M. Babcock, Jennie H. Kwon, for the CDC Prevention Epicenters Program

5. Knowledge, beliefs and practices about COVID-19 infection and vaccination in healthcare personnel at non-acute care facilities.
Armaghan-e-Rehman Mansoor, Armaghan-e-Rehman Mansoor, Caroline A. O’Neil, David McDonald, Victoria J. Fraser, Hilary M. Babcock, Jennie H. Kwon for the CDC Prevention Epicenters Program

Global Health: global health work that does not fall under other basic science pathogenesis work

6. Identification of filarial parasite biomarker candidates in extracellular vesicles isolated from culture media and plasma.
Devyn Yates, Lucia S. Di Maggio, Bruce A. Rosa, Robert W. Sprung

7. Implementation and outcomes of a pilot collaborative surgical hydrocele training in Côte d’Ivoire.
Kevin Montes, Georgina Angoa, Benjamin G. Koudou, Philip Budge

8. Paragonimus kellicotti extracellular vesicles released in vitro or present in lung cysts contain a cysteine protease that is recognized by IgG4 antibodies of infected humans.
Lucia Sanchez Di Maggio, Kerstin Fischer, Devyn Yates, Peter U. Fischer.

Implementation / Public Health

9. Sink drain decontamination intervention successfully reduces long-term colonization of AROs responsible for HAIs.
Erin Newcomer, Caroline O’Neil, Lucy Vogt, David McDonald, Candice Cass, Meghan Wallace, Tiffany Hink, Francesca Yerbic, Carol Muenks, Rebecca Gordon, Henry Stewart, Mostafa Amor, Kevin Jolani, Kelly Alvarado, Alyssa Valencia, Carleigh Samuels, Kate Peacock, Daniel Park, Emily Struttmann, Kimberly Sukhum, Carey-Ann D. Burnham, Gautam Dantas, Jennie Kwon

Pathogenesis: mechanistic studies that work on improving the understanding of a pathogen (bacterial, viral or fungal) or the host response to the pathogen.

10. WHAT DETERMINES HIV VIRAL TROPISM IN VIVO?
Priya Pal¹, Hongbo Gao¹, Liang Shan¹
¹Washington University in St Louis, Department of Internal Medicine, Division of Infectious Disease, St Louis MO

11. Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection.
Somya Aggarwal, Forrest C Walker, Broc T McCune, Heyde Makimaa, Pratyush Sridhar, Megan Baldridge

12. Intranasal vaccination of Syrian Golden Hamsters with ChAd-SARS-CoV-2-S prevents onwards airborne transmission.
Tamarand Darling, Tamarand L. Darling, Houda H. Harastani, Astha Joshi, Traci L. Bricker, Ahmed O. Hassan, Michael S. Diamond, Adrianus C.M. Boon

13. Combinatorial effects of interferons in regulating the pathogenesis of a virulent novel strain of murine norovirus.
Lila Nolan, Forrest C. Walker, PhD, Pooja Shah, Megan T. Baldridge, MD, PhD

14. Myeloid-derived IL-1B promotes loss of neurogenesis and memory deficits during COVID-19 in mice.
Abigail Vanderheiden, Jeremy Hill, Robyn S. Klein

15. The highly conserved stem-loop II motif is dispensable for SARS-CoV-2.
Astha Joshi, Hongbing Jiang, Tianyu Gan, Andrew B Janowski, Chika Fujii, Traci L Bricker, Tamarand L Darling, Houda H. Harastani, Kuljeet Seehra, Stephen Tahan, Ana Jung, Binita Feebles, Joshua A Blatter, Scott A Handley, Bijal A Parikh, David Wang, Adrianus CM Boon

16. Signaling Lymphocyte Activation Molecule Family Member 1 (SLAMF1) promotes protective immunity against Mycobacterium tuberculosis.
G V R Krishna Prasad, SJ Grigsby, C Portal-Celhay, G Erkenswick-Watsa, N. Jain, A Martinot, JD Ernst, JA Philips

17. Central Carbon Flux Controls Growth/Damage Balance during Streptococcal Infection.
Wei Xu, Joseph Merriman, Nicholas Rathmann, Michael Caparon

18. Studying the Transmission of SARS-CoV-2 Using Barcoded Viruses.
Reed Trende, Jacco Boon, David Wang, Tamarand Darling, Tianyu Gan

19. Determining the mechanistic basis for Irgm1 mediated control of Mycobacterium tuberculosis infection.
Sumanta Naik, E. Michael Nehls, Yassin Mreyoud, Rachel L. Kinsella, Asya Smirnov, Chanchal Sur Chowdhury, Samuel R. McKee, Neha Dubey, Darren Kreamalmeyer, Christina L. Stallings.

20. ATG5 suppresses type I IFN-dependent neutrophil swarming and NETosis.
Rachel Kinsella, Chanchal Sur Chowdhury, Asya Smirnov, Yassin Mreyoud, Jacqueline M. Kimmey, Ekaterina Esaulova, Darren Kreamalmeyer, Maxim N. Artyomov, Christina L. Stallings

21. Development of clinically relevant murine models of Acinetobacter baumannii pulmonary infection.
Clay Jackson-Litteken, Joseph Mackel, Gisela Di Venanzio, Mario Feldman

22. The role of tRNA methyltransferases in multi-drug resistant Acinetobacter baumannii pathogenesis.
Jenna McGuffey, Clay D. Jackson-Litteken, Gisela Di Venanzio, Mario F. Feldman

23. Elucidating the role of Mycobacterium tuberculosis CpsA in undermining xenophagy, a lysosomal trafficking pathway.
Jully Sadadiwala, Vinod V. Patil, Jennifer A. Philips

24. CARD8 activation in myeloid cells as a driver of chronic inflammation in HIV infection.
Marilia Rita Pinzone, Liang Shan

25. Interactions between Enterococcus faecalis and Klebsiella pneumoniae in Polymicrobial Catheter-Associated Urinary Tract Infections.
Zongsen Zou, Jerome S. Pinkner, Michael G. Caparon, Scott J. Hultgren

26. Development of adenovirus-mediated gene-editing mice model to explore SARS-CoV-2-host pathogenesis.
Cuncai GUO, Amy Sansone, Maggie Barry, Anthony Orvedahl

27. Enterotoxigenic E. coli toxins impair normal intestinal epithelial cell maturation.
Alaullah Sheikh, James M Fleckenstein

28. Disruption Of 3Î²-hydroxysteroid Dehydrogenase In Mycobacterium Tuberculosis Leads To Increased Virulence And Altered Inflammatory Response.
Andrew Roth, Heloise Coullon, Pallavi Chandra, Jennifer A. Philips

29. Dysbiosis of the gut microbiota induces inflammation in the gut and adipose tissue independent of diet, genetics, and immune development.
Devesha Kulkarni, Brigida Rusconi, Elizabeth L. Joyce and Rodney D. Newberry

30. Durable murine colonization with Staphylococcus aureus using a novel model of neonatal colonization.
Olson Patrick and Juliane Bubeck-Wardenburg

Stewardship

31. Impact of the BioFire® FilmArray® Pneumonia Panel on Antibiotic Prescribing.
Yuenger Valerie, Elizabeth Neuner, PharmD, BCPS, BCIDP, Tamara Krekel, PharmD, BCPS, BCIDP, David Ritchie, PharmD, FCCP, BCIDP